古新梅 Hsin-Mei Ku

經歷

學歷

教授課程

• 遺傳學與實習
• 作物分子育種與實習
• 基因體學與實習
• 作物基因定位分析與實習
• 高等作物遺傳學
• 作物遺傳學特論
• 作物分子遺傳學特論

研究方向

古新梅博士為教育部公費留學生，主攻植物分子遺傳、育種，於美國康乃爾大學植物系完成博士學位，論文指導教授為 Dr. Steven D. Tanksley，畢業後繼續在植物育種系 Dr. Steven D. Tanksley 研究室以及Dr. Susan McCouch 研究室擔任博士後研究員，專長在數量性狀基因座(QTL)的定位分析與選殖、植物重要性狀的分子標誌建立與應用、以及基因體分析，這些專業可以應用在各種不同植物研究角度與層面，回國後任職於中興大學農藝學系。

主要研究方向除了重要作物QTL定位分析之外，近年來研究主要包括植物抗病毒基因的功能性分析以及作物抗病基因座及其他重要農藝性狀基因座連鎖分子標誌之開發，目前主要研究主題為利用基因體分析開發苦瓜重要全雌性及果實相關QTL連鎖分子標誌以及刺角瓜抗病品系對抗PRSV抗性機制之探討。

期刊論文

1. Jen-Ren Chen, Shang-Ling Ou, Ting-Iun Nieh, Chih-Yu Lu, Hsin-Mei Ku* (2020) Molecular dissection of Cucumis metuliferus resistance against Papaya ringspot virus by grafting. Plants 9, 1666 (accepted Nov. 25, 2020)(SCI)
2. S-Y Chen, M-H Su, KA. Kremling, NK. Lepak, MC Romay, Q Sun, PJ Bradbury, ES Buckler and Hsin-Mei Ku* (2020) Identification of miRNA-eQTLs in Maize Mature Leaf by GWAS. BMC Genomics (accepted Sept. 10, 2020)(SCI)
3. Lee, C.-H., Zheng, Y.-X., Chan, C.-H., Ku H.-M.., Chang. C.-J., and Jan, Fuh-Jyh*. (2020) A single amino acid substitution in the movement protein enables the mechanical transmission of a geminivirus. Molecular Plant Pathology: in press (accepted for publication on January 21, 2020) (SCI, IF=4.379, Plant Sciences 15/228= 6.6%).
4. Jen-Ren Chen, Naoya Urasaki, Hideo Matsumura, I-Cheng Chen, Mei-Jiuan Lee, Hui-Ju Chang, Wen-Chuan Chung and Hsin-Mei Ku＊（2019） Dissecting the all-hermaphrodite phenomenon of a rare X chromosome mutant in papaya (Carica papaya L.). Mol Breed 39(1): 14 (SCI) 10.1007/s11032-018-0918-7. Horticulture 6/36 IF 1.862
5. Jen-Ren Chen, Shu-Hui Chen, Ju-Ling Lin and Hsin-Mei Ku* (2018) Advanced methylation-sensitivity amplified polymorphism analysis. Seed and Nursery (accepted in Nov. 6, 2018)
6. Wei-Ting Liu, Peng-Wen Chen, Li-Chi Chen, Chia-Chun Yang, Shu-Yun Chen, GuanFu Huang, Tzu-Che Lin, Hsin-Mei Ku* and Jeremy J.W. Chen* (2017) Suppressive Effect of MicroRNA319 Expression on Rice Plant Height. Theor Appl Genet (2017). 130(7):1507-1518 doi:10.1007/s00122-017-2905-5 (accepted in April, 2017 )(SCI )
7. 古新梅*。王肇芬。 2015。分子輔助抗病育種 。種苗產業發展新趨勢研討會專刊。行政院台南區農業改良場出版。20151127。
8. Chia-Wei Lin, Mei-Hsiu Su, Yu-Tsung Lin, Chien-Hung Chung and Hsin-Mei Ku* (2015) Functional Characterization of Cucumis metuliferus Proteinase Inhibitor Gene (CmSPI) in Potyviruses Resistance. Viruses 7: 3816-3834; doi:10.3390/v7072799 July(SCI )
9. Chia-Wei Lin, Yi-Hua Lin, Yu-Tsung Lin, Wei-Chien Chen, Chien-Teh Chen, Shang-Ling Ou and Hsin-Mei Ku* (2014) Investigation of transgenic tobacco salt and drought tolerance in overexpression of horned melon serine proteinase inhibitor gene in tobacco plants. Crop Environment and Bioinformatics 11(4)
10. Chao-Chin Huang, Shang-Ling Ou, Chong-Zheng Lin, Sz-Yun Chen, Ju-Chieh Chou and Hsin-Mei Ku* (2014) Simulation study of genomic markers for Zucchini yellow mosaic virus Resistance in Winter Squash (Cucurbita moschata). Crop Environment and Bioinformatics 11: 26-38
11. Mulyantoro, Shang-Ling Ou, Shu-Yun Chen, Szu-Chien Liu, Tzu-Chuan Lo, Andi Wahyono, Sz-Yun Chen and Hsin-Mei Ku* (2014) Conversion of genic male sterility (GMS) system of bell pepper (Capsicum annuum L.) to cytoplasmic male sterility (CMS). Plant Breeding 133(2):291-297 (SCI )
12. Jo-Chu Chen, Yen-Chu Wang, Hsin-Pang Tsai, Shyh-Shyan Wang, Hung-Wei Wang, and Hsin-Mei Ku* (2013) Molecular Genetic Characterization of Fruit Firmness and Thickness Loci in Tomato. J. Taiwan Soc. Hort. Sci. 59(3):219-229, 201
13. Yu-Tsung Lin, Fuh-Jyh Jan, Chia-Wei Lin, Tzu-Chuan Lo, Chien-Hung Chung, Jo-Chu Chen, Hsiang-Hao Su, Shy-Dong Yeh, and Hsin-Mei Ku* (2013) Differential Gene Expression in Response to Papaya ringspot virus Infection in Cucumis metuliferus using cDNA- Amplified Fragment Length Polymorphism Analysis. PLOSONE 8(7) e68749 July(SCI )
14. Shu-Yun Chen, Ting-Xuan Dai, Yuan-Tsung Chang, Shyh-Shyan Wang, Shang-Ling Ou, Wen-Ling Chuang, Chih-Yun Cheng, Yi-Hua Lin, Li-Yin Lin and Hsin-Mei Ku* (2013) Genetic diversity among Ocimum species based on ISSR, RAPD and SRAP markers. Austral J Crop Sci 7(10): 1463- 1471
15. Huei-Mei Chen, Hsin-Mei Ku, Roland Schafleitner, Tejinderjit S. Bains, C. George Kuo, Chien-An Liu, and Ramakrishnan M. Nair (2013) The major Quantitative Trait Locus for Mungbean yellow mosaic Indian virus resistance is tightly linked in repulsion phase to the major bruchid resistance locus in a cross between mungbean [Vigna radiata (L.) Wilczek] and its wild relative Vigna radiata ssp. Sublobata. Euphytica July 2013, Volume 192(2) 205-216 (SCI )
16. Kuang‐Ming Hsu, Jinn‐Lai Tsai, Ming‐Yih Chen, Hsin‐Mei Ku*, Szu‐Chien Liu* (2013) Molecular phylogeny of Dioscorea in East and Southeast Asia. Blumea - Biodiversity, Evolution and Biogeography of Plants, 58 (1): 21-27 (SCI )
17. Ching-Yi Lin, Hsin-Mei Ku, Yi-Hua Chiang, Hsiu-Yin Ho, Tsong-Ann Yu,and Jan, Fuh-Jyh*. (2012) Development of transgenic watermelon resistant to Cucumber mosaic virus and Watermelon mosaic virus by using a single chimeric transgene construct Transgenic Res : 21: 983-993*The authors Ching-Yi Lin and Hsin-Mei Ku equally contributed to this work. (SCI)
18. Hsin-Mei Ku, Chee-Wee Tan, Yen-Shuo Su, Chih-Yu Chiu, Chien-Teh Chen*, and Fuh-Jyh Jan* (2012) The effect of water deficienct and excess copper on proline metabolism in Nicotiana benthamiana. Biologia Plantarum 56(2): 337-343 (SCI )
19. Lin, C.-Y., Tsai, W.-S., Ku, Hsin-Mei, and Jan, Fuh-Jyh* (2012) Evaluation of DNA fragments covering the entire genome of a monopartite begomovirus for induction of viral resistance in transgenic plants via gene silencing. Transgenic Res 21(2): 231-241(SCI)
20. Hsin-Mei Ku, Chi-Chien Hu, Hui-Ju Chang, Fuh-Jyh Jan* and Chien-Teh Chen*(2011) Analysis by virus induced gene silencing of the expression of two proline biosynthetic pathway genes in Nicotiana benthamiana under stress condition. Plant Physiol & Biochem 49(10): 1147-1154 (SCI )
21. Yu-Tsung Lin, Chia-Wei Lin, Chien-Hung Chung, Mei-Hsiu Su, Hsiu-Yin Ho, Shi-Dong Yeh, Fuh-Jyh Jan*, and Hsin-Mei Ku* (2011) In Vitro Regeneration and Genetic Transformation of Cucumis metuliferus via Cotyledon Organogenesis. HortScience 46(4): 616-621 (SCI)
22. Ching-Yi LIN, Hsin-Mei KU, Chee-Wee TAN, Shyi-Dong YEH and Fuh-Jyh JAN (2011). Construction of the binary vector with bi-selectable markers for generating marker-free transgenic plants. Bot Stud, 52: 239-248(SCI)
23. Li, Charng-Pei, Huang Shou-Horng, Chen Jen-Ren, Tseng Tung-Hi, Lai Ming-Hsing and Hsin-Mei Ku* (2011) Molecular characterization of introgression lines from a wild rice, Oryza officinalis, with resistance to brown planthopper. J. Taiwan Agric. Res. 60: 263-278
24. Lin, Ching-Yi, Ku, Hsin-Mei, Tsai Wen-Shi, Green Sylvia K., and Jan, Fuh-Jyh (2011) Resistance to a DNA and a RNA virus in transgenic plants by using a single chimeric transgene construct. Transgenic Res. 20(2):261-270. (SCI)
25. Zhong-Bin Wu, Hsin-Mei Ku, Chiou-Chu Su, Iou-Zen Chen and Fuh-Jyh Jan* (2011) Molecular and biological characterization of an isolate of Apple stem pitting virus causing pear vein yellows disease in Taiwan. Journal of Plant Pathology 92:723-730. (SCI)
26. Shu-Yun Chen, Yu-Tsung Lin, Chia-Wei Lin, Wei-Yu Chen, Chih-Hung Yang, and Hsin-Mei Ku* (2010) Transferability of rice SSR markers to bamboo. Euphytica 175: 23-33 (SCI).
27. Wu, Zhong-Bin, Ku, Hsin-Mei, Chen, Yun-Kun, Chang Chung-Jan and Jan, Fuh-Jyh*. (2010). Biological and molecular characterization of Apple chlorotic leaf spot virus causing chlorotic leaf spot on pear (Pyrus pyrifolia) in Taiwan. HortScience 45: 1073-1078 (SCI )
28. Jen-Ren Chen, Hsin-Mei Ku, Jau-Yeuh Wang, and Min-Tze Wu. (2010). Exploitation and Characterization of EST-Derived Microsatellite Markers in Watermelon [Citrullus lanatus (Thunb.) Matsum & Nakai]. J. Taiwan Agric. Res. 58(4)310-315.
29. Chang, Ho-Hsiung, Ku, Hsin-Mei, Tsai, Wen-Shi, Chien Rui-Che, and Jan, Fuh-Jyh*. (2010) Identification and characterization of a mechanical transmissible begomovirus causing leaf curl on oriental melon. European Journal of Plant Pathology 127:219-228 (SCI )
30. Charn-Pei Li, Hsin-Mei Ku, Tzer-Kuan Hui, Chyr-Guan Chern, Ming-Hsing Lai, Ching-Shan Tseng, Jen-Ren Chen, and Tung-Hi Tseng. (2009) Construction of Intregression Lines from Wild Rice (Oryza australiensis Domin) and Assessment of Yield-Related Traits. J. Taiwan Agric. Res. 58:219-233.
31. Mulyantoro, Shu-Yun Chen, Andi Wahyono, and Hsin-Mei Ku* (2009) Modified complementation test of male sterility mutants in pepper (Capsicum annuum L.): preliminary study to convert male sterility system from GMS to CMS. Euphytica 169: 353-361( SCI).
32. Shen, B.-N., Zheng, Y. X., Chen, W. H., Chang, T. Y., Ku, Hsin-Mei, and Jan, Fuh-Jyh * (2009). Occurrence and molecular characterization of three pineapple mealybug wilt-associated viruses in pineapple in Taiwan. Plant Disease 93:196 (SCI)
33. Chang, H.-H., Ku, H.-M., and Jan, Fuh-Jyh*. (2009). Current progress and prospect of the reverse genetics of negative-strand RNA viruses. Plant Pathology Bulletin 18:201-216
34. Chang, H.-H., Tseng, H.-H., Yeh, S.-D., Ku, H.-M.* and Jan, Fuh-Jyh*. (2009). Generation of monoclonal antibody against the replicase of Watermelon silver mottle virus and its application on the detection of L protein expression in planta. Plant Pathology Bulletin 18: 237-246.
35. Lin, C.-Y., Tsai, W.-S., Ku, H.-M.*, and Jan, Fuh-Jyh*. (2009) Transgenic strategies for developing transgenic plants with geminivirus resistance. Plant Pathology Bulletin 18:185-200.
36. Huei-Mei Chen, Chien-An Liu, C. George Kuo, Ching-Mei Chien, Horng-Chi Sun, Chunh-Chu Huang, Yu-Chung Lin and Hsin-Mei Ku * (2007) Development of a molecular marker for a bruchid (Callosobruchus chinensis L.) resistance gene in mungbean. Euphytica 157: 113-122. (SCI)
37. Chong-Zheng Lin, Chang-Pei Li, Shu-Yun Cheng, Yu-Chung Lin, Ai-Na Hsu, Fu-Sheng Thseng, Shu-Tu Wu and Hsin-Mei Ku* (2007) Tagging QTL for Grain Quality Related Traits by Rice SSR Markers. Crop Environment and Bioinformatics 4: 269-284.
38. Meng-Huei Lin, Chia-Wei Lin, Jo-Chu Chen, Yu-Chung Lin, Shu-Yun Cheng, Tzung-Hua Liu, Fuh-Jyh Jan, Shu-Tu Wu, Fu-Sheng Thseng and Hsin-Mei Ku* (2007 ) Tagging Rice Drought-related QTL with SSR DNA Markers. Crop Environment and Bioinformatics 4(1): 65-76.
39. Doganlar S., Frary A., Hsin-Mei Ku, and S. D. Tanksley (2002) Mapping Quantitative Trait Loci in Inbred Backcross Lines of Lycopersicon pimpinellifolium (LA1589) Genome 45:1189-202. (SCI)
40. Ku Hsin-Mei, Liu J.P., Doganlar S., and Tanksley S. D. (2001) Exploitation of Arabidopsis-Tomato synteny to construct a high-resolution map of the ovate locus in tomato chromosome 2. Genome 44: 470-475. (SCI)
41. Ku Hsin-Mei, Vision T., Liu J. and Tanksley S. D. (2000) Comparing segments of the tomato and Arabidopsis genomes: Large-scale duplication followed by selective gene loss creates a network of synteny. Proc. Natl. Acad. Sci. USA 97(16): 9121-9126. (SCI)
42. Ku Hsin-Mei, S. Grandillo and S. D. Tanksley (2000) A major QTL, fs8.1, setting the pattern of tomato carpel shape well before anthesis. Theor. Appl. Genet. 101:873-878 (SCI)
43. Ku Hsin-Mei, S. Doganlar, K.-Y. Chen and S. D. Tanksley (1999) The genetic basis of pear-shaped tomato fruit. Theor. Appl. Genet. 99(5): 844-850 (SCI)
44. Grandillo S, Hsin-Mei Ku, S. D. Tanksley (1999) Identifying the loci responsible for natural variation in fruit size and shape in tomato. Theor. Appl. Genet. 99(6): 978-98. (SCI)
45. Ku Hsin-Mei, and S. D. Tanksley (1998) Round fruit allele of fs8.1 is associated with reduced incidence of blossom-end rot in tomato fruit. Tomato Genet. Coop. Report 48: 28-29.
46. Grandillo S, Hsin-Mei Ku, S. D. Tanksley (1996) Characterization of fs8.1, a major QTL influencing fruit shape in tomato. Molecular Breeding 2: 251-260. (SCI)
47. Ku, H. M. and H. S. Tsay. (1994). Effects of medium composition on the vitrification of carnation seedlings culture in vitro. Jour. Agric. Res. China 43:51-62.
48. Ku, H. M. and H. S. Tsay. (1994). Influence of subculture generation on the vitrification of carnation plantlets culture in vitro. Jour. Agric. Res. China 43:308-319.

Dissertation

• Ku Hsin-Mei (1998) Ph. D. Department of Plant Biology, Cornell University, Ithaca, USA. Dissertation: “Toward map-based cloning of fruit shape QTLs: a major QTL setting the pattern of carpel shape well before anthesis; genetic characterization and molecular mapping, high-resolution genetic and physical mapping of a major locus controlling pear-shaped fruit in tomato”.

Book

• 古新梅*。2020年2月。前瞻基因體學技術於農業領域之研發應用與展望。pp27-42。台大動植物農業產業窗新教育推動中心。ISBN 978-986-5452-17-9。
• Jan, Fuh-Jyh and Ku, H.-M. (2001). Development of transgenic plants resistant to multiple viruses via gene silencing. Pages 239-250 in Proceedings of International Symposium on Biological Control of Plant Diseases for the New Century-Mode of Action and Application Technology. D. S. Tzeng and J. W. Huang, eds., Department of Plant Pathology, National Chung Hsing Univereisty Press, Taichung, Taiwan.